Figure 3

RBD targeted COVID vaccine and full length spike-protein vaccine (mutation and glycosylation role) relationship with procoagulant effect

Luisetto M*, Tarro G, Farhan Ahmad Khan, Khaled Edbey, Mashori GR, Yesvi AR and Latyschev OY

Published: 26 April, 2021 | Volume 5 - Issue 1 | Pages: 001-008

jcavi-aid1007-g003

Figure 3:

SARS-CoV-2, the spike (S) protein and its receptor binding-domain (RBD). (A) Coronaviruses have their name because they are decorated by prominent S proteins (yellow/green). It is the only viral protein that interacts with host cells and is the most diverging protein between different coronaviruses, particularly in its receptor binding-domain (RBD, green). RBD binds to angiotensin converting enzyme 2 (ACE2, not shown) on the host’s cell surface. The fusion peptide (FP) fuses with the host cell membrane. Specific antibodies against RBD and FP can neutralize SARS-CoV-2 NTD/CTD, N-/C-terminal domains. (B) RBD is glycosylated and methylated, which may hinder the induction of neutralizing antibodies. In contrast, the receptor interaction site (RIS, green) is not glycosylated.

Read Full Article HTML DOI: 10.29328/journal.jcavi.1001007 Cite this Article Read Full Article PDF

More Images

Similar Articles

Recently Viewed

  • Survival and predictors of mortality among HIV-infected adults receiving ART in Hawassa comprehensive specialized hospital, Sidama regional state, Ethiopia
    Bargude Balta* and Amanuel Fanta Bargude Balta*,Amanuel Fanta. Survival and predictors of mortality among HIV-infected adults receiving ART in Hawassa comprehensive specialized hospital, Sidama regional state, Ethiopia. J Adv Pediatr Child Health. 2022: doi: 10.29328/journal.japch.1001052; 5: 042-049
  • Dysfunctional breathing in children
    Amanda MP Trompenaars#, Aalt PJ Van Roest# and Anja APH Vaessen-Verberne* Amanda MP Trompenaars#,Aalt PJ Van Roest#,Anja APH Vaessen-Verberne*. Dysfunctional breathing in children. J Pulmonol Respir Res. 2020: doi: 10.29328/journal.jprr.1001013; 4: 001-005
  • COVID-19 disease with persistently negative RT-PCR test for SARS-CoV-2
    Sánchez Ríos Carla Paola*, Jiménez Cabrera Oscar Gabriel, Oropeza Lutzow Rebeca, Vázquez Rojas Hazel, Barreto Rodríguez José Omar, Guzmán-Casta Jordi, Guzmán-Huesca Jorge, Riera-Sala Rodrigo and Centeno Sáenz Gustavo Iván Sánchez Ríos Carla Paola*, Jiménez Cabrera Oscar Gabriel,Oropeza Lutzow Rebeca,Vázquez Rojas Hazel,Barreto Rodríguez José Omar,Guzmán-Casta Jordi,Guzmán-Huesca Jorge,Riera-Sala Rodrigo,Centeno Sáenz Gustavo Iván. COVID-19 disease with persistently negative RT-PCR test for SARS-CoV-2. J Pulmonol Respir Res. 2020: doi: 10.29328/journal.jprr.1001014; 4: 006-010
  • General practitioners’ knowledge, attitudes and practices on antibiotic prescribing for acute respiratory infections in children in Lubumbashi, Democratic Republic of Congo
    Aubin Ndjadi Wembonyama Kasongo, Olivier Mukuku*, Gray A-Wakamb Kanteng, Mick Ya-Pongombo Shongo, André Kabamba Mutombo, Albert Mwembo-A-Nkoy Tambwe, Dieudonné Tshikwej Ngwej, Stanis Okitotsho Wembonyama and Oscar Numbi Luboya Aubin Ndjadi Wembonyama Kasongo,Olivier Mukuku*,Gray A-Wakamb Kanteng,Mick Ya-Pongombo Shongo,André Kabamba Mutombo,Albert Mwembo-A-Nkoy Tambwe,Dieudonné Tshikwej Ngwej,Stanis Okitotsho Wembonyama,Oscar Numbi Luboya. General practitioners’ knowledge, attitudes and practices on antibiotic prescribing for acute respiratory infections in children in Lubumbashi, Democratic Republic of Congo. J Pulmonol Respir Res. 2020: doi: 10.29328/journal.jprr.1001015; 4: 011-017
  • Spontaneous pneumomediastinum associated with COVID-19: Rare complication of 2020 pandemic
    Arnaldo A Nieves-Ortiz*, Vanessa Fonseca-Ferrer, Kyomara Hernández-Moya, Keren Mendez Ramirez, Jose Ayala-Rivera, Marangely Delgado, Juan Garcia-Puebla, Rosangela Fernández-Medero and Ricardo Fernandez-Gonzalez Arnaldo A Nieves-Ortiz*,Vanessa Fonseca-Ferrer, Kyomara Hernández-Moya,Keren Mendez Ramirez,Jose Ayala-Rivera,Marangely Delgado, Juan Garcia-Puebla,Rosangela Fernández-Medero,Ricardo Fernandez-Gonzalez. Spontaneous pneumomediastinum associated with COVID-19: Rare complication of 2020 pandemic. J Pulmonol Respir Res. 2020: doi: 10.29328/journal.jprr.1001016; 4: 018-020

Read More

Most Viewed

Read More

Help ?