Figure 5

RBD targeted COVID vaccine and full length spike-protein vaccine (mutation and glycosylation role) relationship with procoagulant effect

Luisetto M*, Tarro G, Farhan Ahmad Khan, Khaled Edbey, Mashori GR, Ahnaf Ilman, Yesvi AR and Latyschev OY

Published: 26 April, 2021 | Volume 5 - Issue 1 | Pages: 001-008

jcavi-aid1007-g005

Figure 5:

System overview. (A) A sequence of the full-length spike (S) protein contains the N-terminal domain (NTD, 16-291), receptor binding domain (RBD, 330-530), furin cleavage site (S1/S2), fusion peptide (FP, 788-806), central helix (CH, 987-1034), connecting domain (CD, 1080-1135), heptad repeat 2 (HR2, 1163-1210) domain, transmembrane domain (TD, 1214-1234), and cytoplasmic tail (CT, 1235-1273). Representative icons for N-glycans (blue and green) and O-glycan (yellow) are also depicted according to their position in the sequence. (B) Assembly of the head, stalk, and CT domains into a full-length model of the S protein. (C) Fully glycosylated and palmitoylated model of the Open system. (D-F) Magnified view of the N-/O-glycans rendered using the Symbol Nomenclature for Glycans (SNFG) (D, E) and S-palmitoylation of the cytoplasmic tail (F). from Casalino, et al.

Read Full Article HTML DOI: 10.29328/journal.jcavi.1001007 Cite this Article Read Full Article PDF

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